CDKL5 and SKIV2L

Data Source:
BioGRID (two hybrid)

		CDKL5	SKIV2L
Description		cyclin dependent kinase like 5	Ski2 like RNA helicase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Ruffle Membrane Dendrite Cytoplasm Ciliary Basal Body Dendritic Growth Cone Perinuclear Region Of Cytoplasm Ciliary Tip Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Cytosol Ski Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Neuron Migration Protein Phosphorylation Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Protein Autophosphorylation Regulation Of Dendrite Development Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Cilium Assembly	RNA Catabolic Process Exonucleolytic Catabolism Of Deadenylated MRNA Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay
Pathways			Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Estimated glomerular filtration rate ( 31015462)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23577725 20861866) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Platelet count ( 32888494) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) vWF levels ( 30586737)
Interacting Genes		2 interacting genes: MLH1 SKIV2L	14 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 XRN1
Entrez ID		6792	6499
HPRD ID		02190	02724
Ensembl ID		ENSG00000008086	ENSG00000204351
Uniprot IDs		O76039	A0A1U9X8J1 Q15477
PDB IDs		4BGQ
Enriched GO Terms of Interacting Partners?
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