SKIV2L and CDKL5

Data Source:
BioGRID (two hybrid)

		SKIV2L	CDKL5
Description		Ski2 like RNA helicase	cyclin dependent kinase like 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Ski Complex	Nucleus Nucleoplasm Centrosome Ruffle Membrane Dendrite Cytoplasm Ciliary Basal Body Dendritic Growth Cone Perinuclear Region Of Cytoplasm Ciliary Tip Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding
	Biological Process	RNA Catabolic Process Exonucleolytic Catabolism Of Deadenylated MRNA Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay	Neuron Migration Protein Phosphorylation Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Protein Autophosphorylation Regulation Of Dendrite Development Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Regulation Of Cilium Assembly
Pathways		Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23577725 20861866) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Platelet count ( 32888494) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) vWF levels ( 30586737)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		14 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 XRN1	2 interacting genes: MLH1 SKIV2L
Entrez ID		6499	6792
HPRD ID		02724	02190
Ensembl ID		ENSG00000204351	ENSG00000008086
Uniprot IDs		A0A1U9X8J1 Q15477	O76039
PDB IDs			4BGQ
Enriched GO Terms of Interacting Partners?
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