SRMS and SKAP2

Data Source:
BioGRID (protein complementation assay)

		SRMS	SKAP2
Description		src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	src kinase associated phosphoprotein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Innate Immune Response	Signal Transduction Negative Regulation Of Cell Population Proliferation B Cell Activation Protein-containing Complex Assembly
Pathways		PTK6 Down-Regulation	Signal regulatory protein family interactions
Drugs		Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Prostate cancer ( 23535732)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic venous disease ( 28374850) Disease free survival in colon cancer ( 31811950) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular thickness ( 30535121) Monocyte count ( 32888494) Peak expiratory flow ( 30804560) Small cell lung carcinoma ( 28604730) Survival in colon cancer ( 31811950) Systemic lupus erythematosus ( 28714469)
Interacting Genes		5 interacting genes: DUXAP9 NCK2 NEDD4 NEDD4L SKAP2	20 interacting genes: APP BLK DNAJB6 FAM102A FASLG FGR FRK FYB1 FYN HCK KHDRBS1 LCK LYN NCK2 PRAM1 PTK2B SRC SRMS TGFBR1 YES1
Entrez ID		6725	8935
HPRD ID		10250	05558
Ensembl ID		ENSG00000125508	ENSG00000005020
Uniprot IDs		Q9H3Y6	B7Z5R3 O75563
PDB IDs			3OMH
Enriched GO Terms of Interacting Partners?
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