BPI and PRSS2

Data Source:
HPRD (in vitro)

		BPI	PRSS2
Description		bactericidal permeability increasing protein	serine protease 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen
	Molecular Function	Lipopolysaccharide Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Antimicrobial Humoral Response Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Neutrophil Degranulation Innate Immune Response Defense Response To Gram-negative Bacterium	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of Cell Adhesion
Pathways		Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides	Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides
Drugs		Di-Stearoyl-3-Sn-Phosphatidylcholine	Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases			Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Basophil count ( 32888494) Blood protein levels ( 29875488) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Monocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)	Blood protein levels ( 29875488) Pancreatitis ( 23143602)
Interacting Genes		1 interacting genes: PRSS2	7 interacting genes: APP BPI CSN1S1 GLP1R MMP9 SERPINA1 SLPI
Entrez ID		671	5645
HPRD ID		00174	03335
Ensembl ID		ENSG00000101425	ENSG00000275896
Uniprot IDs		P17213	A6XMV9 P07478 Q5NV56 Q6PK75
PDB IDs		1BP1 1EWF
Enriched GO Terms of Interacting Partners?
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