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MAP1B and SNCA
Data Source:
HPRD
(in vitro, in vivo)
MAP1B
SNCA
Description
microtubule associated protein 1B
synuclein alpha
Image
No pdb structure
GO Annotations
Cellular Component
Photoreceptor Outer Segment
Cytosol
Microtubule
Microtubule Associated Complex
Plasma Membrane
Postsynaptic Density
Axon
Dendrite
Growth Cone
Somatodendritic Compartment
Neuronal Cell Body
Varicosity
Dendritic Spine
Perikaryon
Synapse
Perinuclear Region Of Cytoplasm
Apical Dendrite
Basal Dendrite
Hippocampal Mossy Fiber
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Cell Cortex
Actin Cytoskeleton
Membrane
Inclusion Body
Axon
Growth Cone
Platelet Alpha Granule Membrane
Protein-containing Complex
Neuronal Cell Body
Axon Terminus
Perinuclear Region Of Cytoplasm
Supramolecular Fiber
Molecular Function
Actin Binding
Structural Molecule Activity
Protein Binding
Phospholipid Binding
Microtubule Binding
Protein-containing Complex Binding
SNARE Binding
Magnesium Ion Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Actin Binding
Protein Kinase Inhibitor Activity
Fatty Acid Binding
Copper Ion Binding
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Ferrous Iron Binding
Zinc Ion Binding
Oxidoreductase Activity
Kinesin Binding
Hsp70 Protein Binding
Histone Binding
Identical Protein Binding
Alpha-tubulin Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Tau Protein Binding
Phosphoprotein Binding
Phospholipase D Inhibitor Activity
Dynein Complex Binding
Cuprous Ion Binding
Biological Process
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Neuron Migration
Negative Regulation Of Microtubule Depolymerization
Axonogenesis
Synapse Assembly
Response To Mechanical Stimulus
Response To Carbohydrate
Cellular Process
Response To Inorganic Substance
Peripheral Nervous System Axon Regeneration
Dendrite Development
Response To Insecticide
Developmental Maturation
Regulation Of Microtubule Depolymerization
Positive Regulation Of Microtubule Polymerization
Response To Estradiol
Negative Regulation Of Intracellular Transport
Response To Vitamin A
Response To Drug
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Axon Extension
Mitochondrion Transport Along Microtubule
Axon Extension
Induction Of Synaptic Plasticity By Chemical Substance
Establishment Of Monopolar Cell Polarity
Cellular Response To Growth Factor Stimulus
Cellular Response To Peptide Hormone Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Positive Regulation Of Receptor Recycling
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Chemical Synaptic Transmission
Response To Iron(II) Ion
Regulation Of Phospholipase Activity
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Dopamine Secretion
Synaptic Vesicle Exocytosis
Synaptic Vesicle Priming
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Microtubule Polymerization
Receptor Internalization
Protein Destabilization
Response To Magnesium Ion
Negative Regulation Of Transporter Activity
Response To Lipopolysaccharide
Negative Regulation Of Monooxygenase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Interferon-gamma
Cellular Response To Oxidative Stress
Negative Regulation Of Histone Acetylation
SNARE Complex Assembly
Positive Regulation Of SNARE Complex Assembly
Dopamine Biosynthetic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Metabolic Process
Positive Regulation Of Endocytosis
Negative Regulation Of Exocytosis
Positive Regulation Of Exocytosis
Synaptic Vesicle Endocytosis
Positive Regulation Of Inflammatory Response
Synapse Organization
Protein Tetramerization
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Serotonin Uptake
Regulation Of Norepinephrine Uptake
Negative Regulation Of Norepinephrine Uptake
Calcium Ion Homeostasis
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Response To Interleukin-1
Cellular Response To Copper Ion
Cellular Response To Epinephrine Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Supramolecular Fiber Organization
Regulation Of Neuron Death
Negative Regulation Of Neuron Death
Positive Regulation Of Neuron Death
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Positive Regulation Of Glutathione Peroxidase Activity
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Regulation Of Synaptic Vesicle Recycling
Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Chaperone-mediated Autophagy
Regulation Of Presynapse Assembly
Pathways
Amyloid fiber formation
Drugs
Resveratrol
Copper
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Attention deficit hyperactivity disorder (
18839057
)
Coronary artery disease in type 1 diabetes (
29695241
)
Refractive error (
32231278
)
Blood protein levels (
30072576
29875488
)
Dementia with Lewy bodies (
29263008
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Feeling nervous (
29500382
)
Neurociticism (
29500382
)
Parkinson's disease (
22451204
20711177
21084426
21292315
19915575
19915576
25064009
32201043
31660654
27182965
28892059
22438815
28011712
20070850
21044948
24511991
21738487
32310270
)
Parkinson's disease (age of onset) (
31660654
30957308
)
Parkinson's disease in GBA mutation carriers (
31755958
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Response to bupropion in depression (
27622933
)
Interacting Genes
29 interacting genes:
ACTB
ANP32A
ARHGEF11
DYNLL1
EEF1D
ERBB3
FOS
GABRR1
GABRR2
GAN
GSK3B
HTR6
LRRK2
MAG
MAGOH
MAP1A
MAPK8
MARCHF5
MINK1
NXF1
NXF2
PAFAH1B1
RASSF1
SNCA
SPP1
STAU1
STRAP
U2AF1
U2AF2
126 interacting genes:
A1BG
ACTA1
ADAP2
ADRB2
AKT1
AMBRA1
ANXA6
APLP1
APP
ARHGAP15
ARPP19
ARSA
BAD
BAG5
BCL2L1
BDH2
CALM1
CAV1
CDC42EP2
CDC42EP3
CDC42SE1
CDK4
CHRM5
COL25A1
CRYAB
CSNK1A1
CSNK1D
CSNK2A1
CSNK2A2
CTNND1
CTSD
CYCS
DMTN
DNAJC5
DOCK7
DYRK1A
EEF1A1
EGFR
EIF3G
ELK1
ENC1
ENSA
FBXL5
FGR
FKBP4
FYN
GABARAPL1
GAPDH
GBA
GRK1
GRK2
GRK5
GRK6
GSK3B
H1-1
H1-2
HSD17B4
HSP90AA1
HSPB2
HSPB6
HSPB8
KIAA1191
KLC1
KLK6
LYN
MAP1B
MAPK1
MAPK8IP1
MAPT
MEF2D
MT-CO1
MT-CO3
NEDD4
NEDD4L
PAK3
PARK7
PDE4DIP
PDIA2
PELP1
PFDN2
PLCB2
PLD1
PLK1
PLK2
PLK3
PPP3CA
PRDX1
PREP
PRKCE
PRKN
PTK2B
RABAC1
RNF10
SAP30BP
SDF4
SEPTIN4
SIAH2
SLC6A3
SMURF2
SNCAIP
SNCB
SPTBN1
SQSTM1
SRC
SRI
STAMBP
SYK
SYN1
TGM1
TH
TOR1A
TPPP
TUBA1A
UBB
UBC
UBE2D2
UBE2W
USP2
USP47
USP7
USP8
YOD1
YWHAB
YWHAE
YWHAH
ZRANB1
Entrez ID
4131
6622
HPRD ID
01139
01227
Ensembl ID
ENSG00000131711
ENSG00000145335
Uniprot IDs
A2BDK6
P46821
Q6PJD3
Q86X89
H6UYS5
P37840
PDB IDs
1XQ8
2JN5
2KKW
2M55
2N0A
2X6M
3Q25
3Q26
3Q27
3Q28
3Q29
4BXL
4R0U
4R0W
4RIK
4RIL
4ZNN
5CRW
6A6B
6CT7
6CU7
6CU8
6FLT
6H6B
6I42
6L1T
6L1U
6L4S
6LRQ
6OSJ
6OSL
6OSM
6PEO
6PES
6RT0
6RTB
6SST
6SSX
6UFR
6XYO
6XYP
6XYQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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