CTR9 and CNTNAP2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CTR9	CNTNAP2
Description		CTR9 homolog, Paf1/RNA polymerase II complex component	contactin associated protein 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cdc73/Paf1 Complex Nuclear Speck Transcriptionally Active Chromatin	Early Endosome Golgi Apparatus Voltage-gated Potassium Channel Complex Cell Surface Membrane Integral Component Of Membrane Axon Dendrite Axolemma Paranodal Junction Neuronal Cell Body Perikaryon Juxtaparanode Region Of Axon
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding SH2 Domain Binding	Protein Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Blastocyst Growth Blastocyst Hatching Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Receptor Signaling Pathway Via JAK-STAT Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Histone H3-K4 Trimethylation Negative Regulation Of MRNA Polyadenylation Regulation Of Genetic Imprinting Positive Regulation Of Histone H3-K79 Methylation Positive Regulation Of Histone H2B Ubiquitination	Cell Adhesion Brain Development Learning Neuron Recognition Transmission Of Nerve Impulse Striatum Development Limbic System Development Thalamus Development Cerebral Cortex Development Adult Behavior Neuron Projection Development Social Behavior Vocal Learning Clustering Of Voltage-gated Potassium Channels Neuron Projection Morphogenesis Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Vocalization Behavior
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases			Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Migraine ( 27182965)	Age-related hearing impairment ( 24939585) Alzheimer's disease ( 22159054) Alzheimer's disease (late onset) ( 26049409) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimerâ€™s disease and/or vascular dementia (clinical subgroup VaD++) ( 31473137) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Bipolar disorder and schizophrenia ( 20889312) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 30072576 29875488) Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Bone mineral density ( 17903296) Choroid plexus volume ( 31530798) Chronic kidney disease (severe chronic kidney disease vs normal kidney function) in type 1 diabetes ( 27647854) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Crohn's disease ( 26192919) Diabetic kidney disease ( 26305897) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Family history of Alzheimer's disease ( 30617256) Glaucoma ( 30104761) Inflammatory bowel disease ( 26192919) Initial pursuit acceleration ( 29064472) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol x physical activity interaction (1df test) ( 30670697) LDL cholesterol x physical activity interaction (2df test) ( 30670697) Lung function (FEV1/FVC) ( 30061609) Obesity-related traits ( 23251661) Postprandial triglyceride response ( 32603185) QT interval (drug interaction) ( 23459443) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Response to radiotherapy in cancer (late toxicity) ( 24785509) Smoking status (heavy vs never) ( 26423011) Ulcerative colitis ( 26192919) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		7 interacting genes: BLK CNTNAP2 H1-2 SMAD9 SOX4 SUMO2 TCEA1	11 interacting genes: CASK CNTN2 CPE CTR9 EPB41L3 GORASP2 KCNA2 MACF1 MEOX2 POLR2G ZMIZ1
Entrez ID		9646	26047
HPRD ID		06717	05197
Ensembl ID		ENSG00000198730	ENSG00000174469
Uniprot IDs		Q6PD62	A0A090N7T7 B2RCH4 Q9UHC6
PDB IDs		5ZYQ 6GMH 6TED	5Y4M
Enriched GO Terms of Interacting Partners?
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