SNTB1 and KCNJ12

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		SNTB1	KCNJ12
Description		syntrophin beta 1	potassium inwardly rectifying channel subfamily J member 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Cytoplasm Cytoskeleton Focal Adhesion Dystrophin-associated Glycoprotein Complex Protein-containing Complex Sarcolemma Synapse	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding PDZ Domain Binding	Inward Rectifier Potassium Channel Activity Protein Binding
	Biological Process	Muscle Contraction	Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Regulation Of Ion Transmembrane Transport Protein Homotetramerization Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways			Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Dofetilide Ranolazine Miconazole Yohimbine Dronedarone Butamben
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cerebrospinal T-tau levels ( 28247064) Eye morphology ( 29921221) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) JT interval (sulfonylurea treatment interaction) ( 27958378) Myopia (pathological) ( 23406873) Myopia (severe) ( 23933737) Periodontitis (CDC/AAP) ( 24024966) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thalamus volume ( 31530798)	Adult body size ( 32376654) Body mass index ( 28892062 25673413) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)
Interacting Genes		12 interacting genes: ABCA1 ADGRB1 ADRA1D DGKZ DMD DTNA KCNJ12 MAPK12 RPS6KA1 SCN4A SCN5A UTRN	17 interacting genes: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		6641	3768
HPRD ID		02490	09083
Ensembl ID		ENSG00000172164	ENSG00000184185
Uniprot IDs		Q13884	Q14500
PDB IDs
Enriched GO Terms of Interacting Partners?
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