SNTA1 and MTMR2

Data Source:
BioGRID (unspecified method)

		SNTA1	MTMR2
Description		syntrophin alpha 1	myotubularin related protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Cytoplasm Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Synapse Postsynaptic Membrane	Nucleus Cytoplasm Vacuolar Membrane Cytosol Synaptic Vesicle Postsynaptic Density Membrane Axon Dendrite Early Endosome Membrane Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Synaptic Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Identical Protein Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
	Biological Process	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport	Negative Regulation Of Receptor Internalization Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Negative Regulation Of Myelination Myelin Assembly Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Endocytosis Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Neuron Development Regulation Of Phosphatidylinositol Dephosphorylation Negative Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Maintenance Positive Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Receptor Catabolic Process
Pathways			Synthesis of PIPs at the ER membrane Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494) Triglyceride levels x loop diuretics use interaction ( 31806883) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		74 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6	6 interacting genes: ERBB3 ERBB4 NEFL ROR2 SBF1 SNTA1
Entrez ID		6640	8898
HPRD ID		03009	04650
Ensembl ID		ENSG00000101400	ENSG00000087053
Uniprot IDs		Q13424	A0A024R3B7 Q13614
PDB IDs			1LW3 1M7R 1ZSQ 1ZVR 5GNH
Enriched GO Terms of Interacting Partners?
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