SNTA1 and SCN4A

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		SNTA1	SCN4A
Description		syntrophin alpha 1	sodium voltage-gated channel alpha subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Anatomical Structure Cytoplasm Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Synapse Postsynaptic Membrane	Voltage-gated Sodium Channel Complex Integral Component Of Plasma Membrane Axon
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding
	Biological Process	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport	Sodium Ion Transport Muscle Contraction Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Skeletal Muscle Contraction By Action Potential
Pathways			Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs			Ranolazine Topiramate Lidocaine Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Flecainide Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Parachlorophenol Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Hyperkalemic periodic paralysis (HyperPP) Potassium-aggravated myotonias (PAMs), including: Myotonia fluctuans; Myotonia permanens; Acetazolamide responsive myotonia Hypokalemic periodic paralysis (HypoPP) Paramyotonia congenita (PMC) Congenital myasthenic syndrome
GWAS		HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697)	Height ( 28552196 31562340)
Interacting Genes		74 interacting genes: ABCA1 ABCC4 ACTA2 ADAMTS6 ADGRB1 ADGRB2 ADGRB3 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA DTNB F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 RPS6KA1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6	10 interacting genes: CALM1 DLG1 DLG2 DLG3 ERBIN PATJ SLC9A3R1 SNTA1 SNTB1 SNTB2
Entrez ID		6640	6329
HPRD ID		03009	04912
Ensembl ID		ENSG00000101400	ENSG00000007314
Uniprot IDs		Q13424	P35499
PDB IDs			6AGF 6MBA 6MC9
Enriched GO Terms of Interacting Partners?
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