TMEM108 and NOTCH3

Data Source:
BioGRID (pull down)

		TMEM108	NOTCH3
Description		transmembrane protein 108	notch receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Early Endosome Endosome Membrane Postsynaptic Density Integral Component Of Membrane Axon Dendrite Somatodendritic Compartment Axon Cytoplasm	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Molecular_function Protein Binding	Calcium Ion Binding Protein Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding
	Biological Process	Receptor-mediated Endocytosis Retrograde Axonal Transport Biological_process Dentate Gyrus Development Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Postsynaptic Density Organization Dendrite Extension Modulation Of Excitatory Postsynaptic Potential Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Axon Guidance Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process
Pathways			Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases			Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Chronotype ( 30696823) IgE grass sensitization ( 22036096) Iron status biomarkers (total iron binding capacity) ( 28334935) Menarche (age at onset) ( 27182965 21102462) Systolic blood pressure ( 30224653 30578418) Waist circumference ( 28552196)	Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)
Interacting Genes		7 interacting genes: ANXA7 ARHGEF6 FHL3 FKBP7 NOTCH3 SGTB SH3GL2	48 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B LINC00839 MAML1 MAML2 MAML3 MPPED2 MTDH MYC NEDD9 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8
Entrez ID		66000	4854
HPRD ID		11329	02607
Ensembl ID		ENSG00000144868	ENSG00000074181
Uniprot IDs		B3KT64 Q6UXF1	Q9UM47
PDB IDs			4ZLP 5CZV 5CZX
Enriched GO Terms of Interacting Partners?
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