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NOTCH3 and RBPJ
Data Source:
HPRD
(in vivo)
NOTCH3
RBPJ
Description
notch receptor 3
recombination signal binding protein for immunoglobulin kappa J region
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Nucleoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Cell Surface
Actin Cytoskeleton
Integral Component Of Membrane
Receptor Complex
Chromatin
MAML1-RBP-Jkappa- ICN1 Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Transcription Repressor Complex
Molecular Function
Calcium Ion Binding
Protein Binding
Signaling Receptor Activity
Identical Protein Binding
Cadherin Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Sequence-specific DNA Binding
Protein N-terminus Binding
Repressing Transcription Factor Binding
Biological Process
Transcription Initiation From RNA Polymerase II Promoter
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Axon Guidance
Negative Regulation Of Notch Signaling Pathway
Regulation Of Developmental Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Somitogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Inflammatory Response To Antigenic Stimulus
Secondary Heart Field Specification
Outflow Tract Morphogenesis
Endocardium Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cardiac Left Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Humoral Immune Response
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Negative Regulation Of Cell Population Proliferation
Auditory Receptor Cell Fate Commitment
Epidermal Cell Fate Specification
Positive Regulation Of Gene Expression
Pituitary Gland Development
B Cell Differentiation
Keratinocyte Differentiation
Negative Regulation Of Ossification
Positive Regulation Of BMP Signaling Pathway
Somatic Stem Cell Population Maintenance
Dorsal Aorta Morphogenesis
Atrioventricular Canal Development
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Negative Regulation Of Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Timing Of Cell Differentiation
Sebaceous Gland Development
Hair Follicle Maturation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Ventricular Septum Morphogenesis
Club Cell Differentiation
Labyrinthine Layer Blood Vessel Development
Arterial Endothelial Cell Fate Commitment
Notch Signaling Involved In Heart Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Blood Vessel Lumenization
Blood Vessel Endothelial Cell Fate Specification
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of ERBB Signaling Pathway
Positive Regulation Of Ephrin Receptor Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in Golgi
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Noncanonical activation of NOTCH3
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS
Pulse pressure (
27841878
30578418
)
Toxoplasma gondii sag1 antibody levels (
33204752
)
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
Autoimmune traits (pleiotropy) (
30572963
)
Heel bone mineral density (
30598549
)
Medication use (thyroid preparations) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Rheumatoid arthritis (
24449572
23143596
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Triglyceride levels (
32203549
32154731
)
Interacting Genes
48 interacting genes:
ANKRD28
BAG2
BTF3L4
C1QL1
C8orf76
CBFA2T2
CHUK
CNTD1
CPNE6
CRIP2
CSNK2B
DLL1
EGFL7
FBLN1
GGT6
JAG1
JAG2
KAT2B
LINC00839
MAML1
MAML2
MAML3
MPPED2
MTDH
MYC
NEDD9
PPIA
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSEN1
PSEN2
RBPJ
RET
RMI2
SCGB3A1
SLC39A1
SNW1
SNX19
SORBS3
SPTLC2
TMEM108
TNNT2
TPT1
WDR25
XKR8
28 interacting genes:
APP
CCNF
CIR1
FHL1
GADD45A
GSK3B
HDAC1
HMGB1
HSPB1
KAT2A
KAT2B
MAML1
MED27
NCOR1
NCOR2
NOTCH1
NOTCH2
NOTCH3
NOTCH4
PTF1A
RPS6KA6
SIN3A
SND1
SNW1
SPEN
SPOP
SUFU
TP53
Entrez ID
4854
3516
HPRD ID
02607
00920
Ensembl ID
ENSG00000074181
ENSG00000168214
Uniprot IDs
Q9UM47
Q06330
PDB IDs
4ZLP
5CZV
5CZX
2F8X
3NBN
3V79
6PY8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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