FUNDC2 and EIF6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FUNDC2	EIF6
Description		FUN14 domain containing 2	eukaryotic translation initiation factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Integral Component Of Mitochondrial Outer Membrane	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome
	Molecular Function	Protein Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Autophagy Of Mitochondrion	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs			Copper
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		37 interacting genes: AQP6 ARL13B ARL15 ASCC2 ATP13A2 CD79A CIDEB COX20 CRB3 CYB5R3 EBP EIF6 EVI2B FCER1G FGF14 GPR152 KCNJ6 KIR2DL3 MFSD14B MGST3 NACA NSF NUDT21 REEP4 RETREG3 RGS1 SAT1 SDR16C5 SLC10A6 SLC16A10 SLC66A2 STOM SYT2 TMEM154 TMX2 TP53I3 USP13	41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26
Entrez ID		65991	3692
HPRD ID		06586	04221
Ensembl ID		ENSG00000165775	ENSG00000242372
Uniprot IDs		Q9BWH2	P56537
PDB IDs			6LQM 6LSR 6LSS 6LU8
Enriched GO Terms of Interacting Partners?
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