SMARCC1 and PPIP5K2

Data Source:
BioGRID (two hybrid)

		SMARCC1	PPIP5K2
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1	diphosphoinositol pentakisphosphate kinase 2
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GO Annotations	Cellular Component	Chromatin XY Body Nucleus Nucleoplasm Cytoplasm SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex	Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding Nucleosomal DNA Binding Histone Binding Protein N-terminus Binding	Inositol-1,3,4,5,6-pentakisphosphate Kinase Activity Inositol Hexakisphosphate Kinase Activity Inositol Heptakisphosphate Kinase Activity Inositol Hexakisphosphate 5-kinase Activity ATP Binding Diphosphoinositol-pentakisphosphate Kinase Activity Inositol Hexakisphosphate 1-kinase Activity Inositol Hexakisphosphate 3-kinase Activity 5-diphosphoinositol Pentakisphosphate 3-kinase Activity
	Biological Process	Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Insulin Receptor Signaling Pathway Animal Organ Morphogenesis Prostate Gland Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Inositol Metabolic Process Sensory Perception Of Sound Phosphorylation Inositol Phosphate Biosynthetic Process Inositol Phosphate Metabolic Process
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Synthesis of pyrophosphates in the cytosol
Drugs
Diseases
GWAS		Household income (MTAG) ( 31844048) Renal underexcretion gout ( 32238385) Systolic blood pressure ( 31928498)	Insulinogenic index ( 23263489) Intelligence (MTAG) ( 29326435) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Type 2 diabetes ( 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		53 interacting genes: ADAMTSL4 ADD1 AKT1 CCNE1 CEBPB CFP CIDEB CYSRT1 EWSR1 FANCA FUS GATA1 GLRX3 GSTO2 ITCH KLF1 KRTAP13-3 KRTAP19-2 KRTAP21-2 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 LRP2BP MGAT5B MSL1 MYC NCOA1 NEDD4 NONO NR3C1 OTX1 PLSCR1 PPIP5K2 PRMT5 PTH1R RELB SIN3A SLC15A2 SMARCA4 SMARCD3 SP1 SPATA12 TAF15 TRIM42 UFSP1 VGLL3 ZNF581	3 interacting genes: POU2F1 POU6F2 SMARCC1
Entrez ID		6599	23262
HPRD ID		03435	13802
Ensembl ID		ENSG00000173473	ENSG00000145725
Uniprot IDs		Q58EY4 Q92922	A0A087WZV0 B4DGV1 O43314
PDB IDs		2YUS 5GJK 6KZ7	3T54 3T7A 3T99 3T9A 3T9B 3T9C 3T9D 3T9E 3T9F 4HN2 4NZM 4NZN 4NZO 4Q4C 4Q4D 5BYA 5BYB 5DGH 5DGI 6N5C
Enriched GO Terms of Interacting Partners?
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