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SMARCA4 and PALS2
Data Source:
HPRD
(two hybrid)
SMARCA4
PALS2
Description
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
protein associated with LIN7 2, MAGUK family member
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Extracellular Space
Nucleus
Nucleoplasm
Nucleolus
Membrane
SWI/SNF Complex
Protein-containing Complex
NpBAF Complex
NBAF Complex
Plasma Membrane
Membrane
Extracellular Exosome
Molecular Function
RNA Polymerase I Core Promoter Sequence-specific DNA Binding
P53 Binding
DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
Transcription Factor Binding
Tat Protein Binding
Nucleosomal DNA Binding
Protein N-terminus Binding
Androgen Receptor Binding
DNA Polymerase Binding
Lysine-acetylated Histone Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase I Preinitiation Complex Assembly
Neural Retina Development
Chromatin Organization
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Nervous System Development
Positive Regulation Of Wnt Signaling Pathway
Negative Regulation Of Cell Growth
Interleukin-7-mediated Signaling Pathway
ATP-dependent Chromatin Remodeling
Positive Regulation By Host Of Viral Transcription
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Androgen Receptor Signaling Pathway
Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Positive Regulation Of Glucose Mediated Signaling Pathway
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Beta-catenin-TCF Complex Assembly
Protein-containing Complex Assembly
Pathways
Interleukin-7 signaling
Formation of the beta-catenin:TCF transactivating complex
RMTs methylate histone arginines
Chromatin modifying enzymes
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Apolipoprotein B levels (
32203549
)
Coronary artery disease (
32469254
24262325
30104761
33020668
)
Coronary artery disease or ischemic stroke (
24262325
)
Coronary artery disease or large artery stroke (
24262325
)
Disorders of lipid metabolism (
30166351
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
Inflammatory skin disease (
25574825
)
Ischemic stroke (
29531354
)
LDL cholesterol (
21347282
)
LDL cholesterol levels (
32203549
30698716
)
LDL cholesterol levels in current drinkers (
30698716
)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Low density lipoprotein cholesterol levels (
31969989
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Multiple sclerosis (
31604244
)
Response to statins (LDL cholesterol change) (
31969989
)
Stroke (
29531354
)
Interacting Genes
80 interacting genes:
ACTB
ACTL6A
AHR
AR
ARID1A
ARID1B
ARID2
BRCA1
BRWD1
CARM1
CBX5
CCNE1
CDK19
CDK8
CDKN2A
CDX2
CEBPA
CEBPB
CHD4
CHFR
CHMP5
CIITA
CREB1
CTNNB1
E2F6
ESR1
ETS2
FANCA
GATA1
GMNN
H2AX
H2BC21
H3-3A
H3C1
H3C14
H4C6
HSF1
HSF4
HSPB1
IKZF1
KLF1
MBD3
MDM2
MED17
MED6
MPHOSPH6
MRTFA
MYC
MYOCD
NR3C1
NR4A2
PABPN1
PALS2
PAX6
PBRM1
PHB
PTEN
RAP1A
RASSF1
RB1
RBL1
RBL2
RELB
RFXAP
SIN3A
SIN3B
SMARCB1
SMARCC1
SMARCE1
SOX4
SS18
SS18L1
STAT2
STAT3
STK11
SUMO2
TAF15
TMF1
TP53
ZMYND11
30 interacting genes:
AATF
ABCA1
ARHGAP18
DIS3
DNM2
DYNLRB1
EIF3G
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FTL
KHDRBS1
KNSTRN
LIN7A
LIN7B
LIN7C
MT2P1
MTREX
NDN
NFKB1
PARN
RPS20
SMARCA4
SNX9
THOP1
Entrez ID
6597
51678
HPRD ID
04459
09509
Ensembl ID
ENSG00000127616
ENSG00000105926
Uniprot IDs
A7E2E1
B3KNW7
P51532
Q9HBD4
A0A024RA25
B8ZZG1
Q9NZW5
PDB IDs
2GRC
2H60
3UVD
5DKD
5EA1
6BGH
6HR2
6LTH
6LTJ
6SY2
6ZS2
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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