SLAMF1 and SH2D1B

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SLAMF1	SH2D1B
Description		signaling lymphocytic activation molecule family member 1	SH2 domain containing 1B
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane Extracellular Exosome	Cytosol
	Molecular Function	Virus Receptor Activity Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding SH2 Domain Binding Identical Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Adaptive Immune Response Myeloid Dendritic Cell Activation Involved In Immune Response Phagocytosis Cell Adhesion Positive Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of JNK Cascade Lymphocyte Activation Viral Entry Into Host Cell Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of CD40 Signaling Pathway	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Natural Killer Cell Mediated Immunity Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Memory decline ( 31985465) Microalbuminuria ( 26631737) Multiple sclerosis ( 31604244) Schizophrenia (treatment resistant) ( 22479419)	Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Takayasu arteritis ( 25604533)
Interacting Genes		6 interacting genes: FGR FYN INPP5D PTPN11 SH2D1A SH2D1B	25 interacting genes: AGR2 APP AR BLK CD244 CD84 EGFR ERBB2 ERBB3 ERBB4 GAB1 KIT LY9 MAGEB4 MAPK8IP2 MEOX2 MET NFKBID NUTM1 PRDX1 PTK2 SLAMF1 STAT4 TNK2 TRIM54
Entrez ID		6504	117157
HPRD ID		04603	12248
Ensembl ID		ENSG00000117090	ENSG00000198574
Uniprot IDs		Q13291	O14796
PDB IDs		1D4T 1D4W 1I3Z 1KA6 1KA7 1M27 2DZF 2IE9 2IFL 2IG5	5KAZ
Enriched GO Terms of Interacting Partners?
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