SIX3 and TLE1

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vitro)

		SIX3	TLE1
Description		SIX homeobox 3	TLE family member 1, transcriptional corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Signaling Receptor Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Repressing Transcription Factor Binding
	Biological Process	Eye Development Epithelial Cell Maturation Lens Development In Camera-type Eye Optic Vesicle Morphogenesis Regulation Of Transcription By RNA Polymerase II Brain Development Visual Perception Proximal/distal Axis Specification Neuroblast Differentiation Telencephalon Development Forebrain Dorsal/ventral Pattern Formation Cell Proliferation In Forebrain Telencephalon Regionalization Pituitary Gland Development Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neural Retina Development Lens Fiber Cell Differentiation Neuroblast Migration Regulation Of Cell Cycle Phase Transition Regulation Of Neuroblast Proliferation Apoptotic Process Involved In Development Lens Fiber Cell Apoptotic Process Regulation Of Neural Precursor Cell Proliferation	Signal Transduction Multicellular Organism Development Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Anoikis
Pathways			Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases		Holoprosencephaly (HPE)
GWAS		Adventurousness ( 30643258) Alcohol and nicotine co-dependence ( 22488850) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol use disorder ( 30940813) Blood sugar levels ( 29403010) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Clozapine-induced myocarditis in schizophrenia ( 32066683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 25187374) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General risk tolerance (MTAG) ( 30643258) Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Intraocular pressure ( 29785010 31959993 30054594) Irritable mood ( 29500382) Lung cancer ( 28604730) Metabolite levels ( 21909109) Myopia ( 27182965) Optic disc size ( 31809533) Problematic alcohol use ( 32451486) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Self-reported risk-taking behaviour ( 30271922) Smoking behaviour (cigarette pack-years) ( 30679032) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 32499647)	Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 32499647 30718926 28869590) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Interacting Genes		7 interacting genes: EYA1 GMNN NR4A3 PAX6 TLE1 TLE3 TLE5	84 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TLX3 TSC22D1 UTY ZFP64
Entrez ID		6496	7088
HPRD ID		04756	02557
Ensembl ID		ENSG00000138083	ENSG00000196781
Uniprot IDs		O95343	B4DEF9 Q04724 Q59EF7
PDB IDs			1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?
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