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SIX3
Description
SIX homeobox 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Transcription Regulator Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Signaling Receptor Binding
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Eye Development
Epithelial Cell Maturation
Lens Development In Camera-type Eye
Optic Vesicle Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Brain Development
Visual Perception
Proximal/distal Axis Specification
Neuroblast Differentiation
Telencephalon Development
Forebrain Dorsal/ventral Pattern Formation
Cell Proliferation In Forebrain
Telencephalon Regionalization
Pituitary Gland Development
Regulation Of Cell Population Proliferation
Negative Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Neural Retina Development
Lens Fiber Cell Differentiation
Neuroblast Migration
Regulation Of Cell Cycle Phase Transition
Regulation Of Neuroblast Proliferation
Apoptotic Process Involved In Development
Lens Fiber Cell Apoptotic Process
Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
Holoprosencephaly (HPE)
GWAS
Adventurousness (
30643258
)
Alcohol and nicotine co-dependence (
22488850
)
Alcohol consumption (
31358974
)
Alcohol consumption (drinks per week) (
30643258
30679032
)
Alcohol use disorder (
30940813
)
Blood sugar levels (
29403010
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Clozapine-induced myocarditis in schizophrenia (
32066683
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Fasting blood glucose (
29621232
)
Fasting plasma glucose (
25187374
)
Fish- and plant-related diet (
32066663
)
Fruit consumption (
32066663
)
General risk tolerance (MTAG) (
30643258
)
Glycated hemoglobin levels (
29170429
)
Hemoglobin A1c levels (
29403010
)
Intraocular pressure (
29785010
31959993
30054594
)
Irritable mood (
29500382
)
Lung cancer (
28604730
)
Metabolite levels (
21909109
)
Myopia (
27182965
)
Optic disc size (
31809533
)
Problematic alcohol use (
32451486
)
Refractive error (
32231278
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Self-reported risk-taking behaviour (
30271922
)
Smoking behaviour (cigarette pack-years) (
30679032
)
Smoking initiation (
30617275
)
Smoking initiation (ever regular vs never regular) (
30679032
)
Smoking status (ever vs never smokers) (
30643258
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Type 2 diabetes (
32499647
)
Interacting Genes
7 interacting genes:
EYA1
GMNN
NR4A3
PAX6
TLE1
TLE3
TLE5
Entrez ID
6496
HPRD ID
04756
Ensembl ID
ENSG00000138083
Uniprot IDs
O95343
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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