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TLE1 and HES1
Data Source:
HPRD
(two hybrid, in vitro)
TLE1
HES1
Description
TLE family member 1, transcriptional corepressor
hes family bHLH transcription factor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Beta-catenin-TCF Complex
Nucleus
Nucleoplasm
Cytoplasm
Protein-containing Complex
Molecular Function
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Identical Protein Binding
Repressing Transcription Factor Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Chaperone Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Signal Transduction
Multicellular Organism Development
Animal Organ Morphogenesis
Positive Regulation Of Gene Expression
Wnt Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin-TCF Complex Assembly
Negative Regulation Of Anoikis
Negative Regulation Of Transcription By RNA Polymerase II
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Nervous System Development
Positive Regulation Of Cell Population Proliferation
Anterior/posterior Pattern Specification
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Cell Fate Determination
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Pathways
Formation of the beta-catenin:TCF transactivating complex
NOTCH1 Intracellular Domain Regulates Transcription
Deactivation of the beta-catenin transactivating complex
Repression of WNT target genes
Repression of WNT target genes
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS
Forehead morphology (
29921221
)
Hippocampal atrophy (
22745009
)
Lung adenocarcinoma (
28604730
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Moderate-to-late spontaneous preterm birth (
31194736
)
Rheumatoid arthritis (
30891314
)
Schizophrenia (
25056061
)
Type 2 diabetes (
22885922
24509480
30054458
30297969
26818947
32499647
30718926
28869590
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral fat (
22589738
)
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Interacting Genes
84 interacting genes:
ANXA7
APH1A
ARL3
ARL4D
ATN1
BARHL1
BCL2L1
BID
BTBD2
CCL18
CDK1
CDKN1A
CDKN2C
CELF3
CRCT1
CSNK2B
CTNNB1
DAZAP2
DLEU1
EIF2S2
EN1
ERH
ESRRG
FOXA1
FOXA2
FOXA3
FOXG1
FUBP1
FXYD6
GADD45A
GRB7
GSK3B
GSTM4
HES1
HES6
HESX1
HHEX
HLA-DQA1
HMGB1
HNF1A
HSPE1
IL6ST
KDM6A
KIAA0408
LEF1
MORF4L2
MPHOSPH6
MSX1
MSX2
NKX2-5
NUDT21
PAFAH1B3
PAX9
PCDHA4
PEX2
PFN1
POLB
POLE2
PRDM1
PSMD11
RAP1B
RCC1
RNF10
RPA2
RUNX1
RUNX3
SAT1
SERPINB9
SIX1
SIX2
SIX3
SIX6
SMN1
SNRPG
TCF3
TCF4
TK1
TLE2
TLX1
TLX2
TLX3
TSC22D1
UTY
ZFP64
35 interacting genes:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY1
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
Entrez ID
7088
3280
HPRD ID
02557
00770
Ensembl ID
ENSG00000196781
ENSG00000114315
Uniprot IDs
B4DEF9
Q04724
Q59EF7
Q14469
PDB IDs
1GXR
2CE8
2CE9
4OM2
4OM3
5MWJ
2MH3
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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