BMP1 and LAMB3

Data Source:
HPRD (in vitro, in vivo)

		BMP1	LAMB3
Description		bone morphogenetic protein 1	laminin subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Laminin Complex Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding	Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Protein-containing Complex Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Multicellular Organism Development Extracellular Matrix Disassembly Cell Differentiation High-density Lipoprotein Particle Assembly Positive Regulation Of Cartilage Development	Epidermis Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Basement Membrane Assembly
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling
Drugs
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Waist-to-hip ratio adjusted for BMI ( 28552196)	Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours) ( 26566055)
Interacting Genes		14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	6 interacting genes: BMP1 COL7A1 LAMA3 LAMC2 MDFI THBS1
Entrez ID		649	3914
HPRD ID		00209	01032
Ensembl ID		ENSG00000168487	ENSG00000196878
Uniprot IDs		P13497	A0A0S2Z3R6 Q13751
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
Enriched GO Terms of Interacting Partners?
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