LAMB3 and BMP1

Data Source:
HPRD (in vitro, in vivo)

		LAMB3	BMP1
Description		laminin subunit beta 3	bone morphogenetic protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Laminin Complex Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Golgi Apparatus Vesicle
	Molecular Function	Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Protein-containing Complex Binding	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Epidermis Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Basement Membrane Assembly	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Multicellular Organism Development Extracellular Matrix Disassembly Cell Differentiation High-density Lipoprotein Particle Assembly Positive Regulation Of Cartilage Development
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling	Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours) ( 26566055)	Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		6 interacting genes: BMP1 COL7A1 LAMA3 LAMC2 MDFI THBS1	14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		3914	649
HPRD ID		01032	00209
Ensembl ID		ENSG00000196878	ENSG00000168487
Uniprot IDs		A0A0S2Z3R6 Q13751	P13497
PDB IDs			3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
Enriched GO Terms of Interacting Partners?
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