ST3GAL4 and GGCX

Data Source:
HPRD (in vivo, in vitro)

		ST3GAL4	GGCX
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 4	gamma-glutamyl carboxylase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Membrane Integral Component Of Membrane Golgi Cisterna Membrane	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Neolactotetraosylceramide Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity	Gamma-glutamyl Carboxylase Activity Vitamin Binding
	Biological Process	Protein Glycosylation Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process O-glycan Processing Keratan Sulfate Biosynthetic Process Positive Regulation Of Blood Coagulation Lipid Glycosylation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling Protein Sialylation	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs			Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 24097068 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 31666285 29403010) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 28334899 30275531) vWF levels ( 30586737)	Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: ARHGDIA CD8B	7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2
Entrez ID		6484	2677
HPRD ID		00084	00665
Ensembl ID		ENSG00000110080	ENSG00000115486
Uniprot IDs		Q11206 Q6IBE6	P38435
PDB IDs
Enriched GO Terms of Interacting Partners?
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