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EPHA1 and SMURF1
Data Source:
BioGRID
(enzymatic study)
EPHA1
SMURF1
Description
EPH receptor A1
SMAD specific E3 ubiquitin protein ligase 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Neuron Projection
Receptor Complex
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Axon
Neuronal Cell Body
Extracellular Exosome
Molecular Function
Fibronectin Binding
Protein Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane-ephrin Receptor Activity
ATP Binding
Protein Kinase Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Phospholipid Binding
Activin Binding
Ubiquitin Protein Ligase Activity
I-SMAD Binding
R-SMAD Binding
Biological Process
Angiogenesis
Positive Regulation Of Cell-matrix Adhesion
Negative Regulation Of Protein Kinase Activity
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Positive Regulation Of Cell Population Proliferation
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Negative Regulation Of Cell Migration
Positive Regulation Of Kinase Activity
Substrate Adhesion-dependent Cell Spreading
Somatic Stem Cell Population Maintenance
Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Ephrin Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Activation Of GTPase Activity
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Export From Nucleus
Transforming Growth Factor Beta Receptor Signaling Pathway
Ectoderm Development
Protein Ubiquitination
Cell Differentiation
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Receptor Catabolic Process
Protein Localization To Cell Surface
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Engulfment Of Target By Autophagosome
Substrate Localization To Autophagosome
Protein Targeting To Vacuole Involved In Autophagy
Protein Localization To Plasma Membrane
Positive Regulation Of Dendrite Extension
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
EPH-Ephrin signaling
EPH-Ephrin signaling
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
Signaling by BMP
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Asymmetric localization of PCP proteins
Hedgehog 'on' state
Hedgehog 'on' state
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Fostamatinib
Diseases
GWAS
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
21460841
30617256
24162737
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Alzheimer's disease or HDL levels (pleiotropy) (
30805717
)
Blood protein levels (
30072576
29875488
28240269
)
Family history of Alzheimer's disease (
30617256
)
Facial emotion recognition (sad faces) (
28608620
)
Inflammatory bowel disease (
28067908
23128233
)
Lack of premeditation (
30718321
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Ulcerative colitis (
28067908
20228798
)
Interacting Genes
12 interacting genes:
CTDSP2
DAPK1
DUSP14
EFNA1
ERBB2
GJB1
MAP3K1
MTMR14
PTPN11
SMURF1
SMURF2
TPTE
189 interacting genes:
ADRM1
ANAPC5
ANKRD13A
ANKRD13D
ANKRD50
ANKS4B
ANXA6
AP2B1
APBB2
APP
ARHGAP15
ARHGAP31
ARHGEF9
ARL14
ARL4D
ASCC2
ASH2L
ATXN3
AVEN
AXIN1
BMPR2
BTK
BTRC
C9orf78
CALCOCO1
CCDC69
CCM2
CDC40
CDK14
CDKL1
CSNK1D
CSNK2A2
CTNNB1
CTNND1
CTTN
CUEDC1
CUL5
CXXC1
DDX54
DNAJC7
DUSP13
DVL2
ECSIT
ELOF1
ELP3
ENTR1
EPHA1
EPN1
ETV6
FAF2
FBXL15
FBXO3
FBXO30
FCHO1
FES
FGF12
FGR
FKBP3
FSCN1
FZR1
GNG11
GRIPAP1
GRK3
HDGFL3
HIP1
HOMER2
ILRUN
IMPACT
ING2
INPP5B
IRAK2
ITGB1BP1
ITK
JUNB
KRT36
LATS1
LCK
LHX9
LIMS1
LMNA
LONRF3
MAP3K10
MAP3K2
MAP3K3
MAP3K9
MAP4K5
MARK2
MATK
MINDY3
MSN
NAA16
NDFIP2
NEDD8
NEK2
ODF2
OTUD6B
OXSR1
PADI4
PAK1
PAK1IP1
PDGFRA
PDLIM7
PICALM
PIP5K1C
PLEKHO1
POLR2A
PRKCA
PRKCG
PRKCI
PRR16
PSMD4
PSME3
PWP1
RABEP1
RAD23A
RASD2
RBCK1
RHOA
RHOB
RHPN2
RIOK3
RIPK2
RIT1
RNF11
RNF114
RNF141
RPS27A
RRP9
RTKN
RUNX3
SASH3
SCYL1
SENP8
SF3A1
SLAIN2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SPART
SQSTM1
SRSF4
SRSF5
STK31
STK35
STRAP
STUB1
TAB1
TAOK3
TBK1
TLN1
TNIK
TNIP2
TNK2
TNNT1
TOM1
TOM1L2
TPM4
TRAF4
TRIP10
TTC17
UBA52
UBAC1
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2K
UBE2L3
UBE2M
UBE2V1
UBQLN1
UBQLN2
UBTF
UBXN1
UBXN6
UBXN7
USP45
USP5
USP9X
WDR61
WEE1
WFS1
XPO1
ZFAND5
Entrez ID
2041
57154
HPRD ID
01554
06902
Ensembl ID
ENSG00000146904
ENSG00000198742
Uniprot IDs
P21709
Q9HCE7
PDB IDs
2K1K
2K1L
3HIL
3KKA
2LAZ
2LB0
2LB1
2LTX
3PYC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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