SCN8A and FGF14

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		SCN8A	FGF14
Description		sodium voltage-gated channel alpha subunit 8	fibroblast growth factor 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Axon Initial Segment	Extracellular Region Nucleus Cytoplasm
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding ATP Binding	Protein Binding Growth Factor Activity Sodium Channel Regulator Activity
	Biological Process	Sodium Ion Transport Nervous System Development Peripheral Nervous System Development Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Membrane Depolarization During Action Potential	Signal Transduction Cell-cell Signaling Nervous System Development Regulation Of Synaptic Plasticity Regulation Of Postsynaptic Membrane Potential Positive Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Synaptic Vesicle Recycling Regulation Of Voltage-gated Sodium Channel Activity
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Phase 0 - rapid depolarisation
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)	Bone mineral density (hip) ( 30172743) Idiopathic downbeat nystagmus ( 32157568) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Maximum habitual alcohol consumption ( 31151762) Plasma parathyroid hormone levels ( 30134803) PR interval ( 32439900) Preeclampsia ( 23551011) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132) Response to protease inhibitor treatment in hepatitis c (bilirubin toxicity) ( 24503447) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		4 interacting genes: FGF13 FGF14 GNAO1 MAPK14	13 interacting genes: ACACA EHHADH FBXO34 FKBP8 FUNDC2 H4C7 HOXD12 MAOB RTP5 SCN8A SMC1A SYT16 TTPA
Entrez ID		6334	2259
HPRD ID		09006	03305
Ensembl ID		ENSG00000196876	ENSG00000102466
Uniprot IDs		Q6B4S4 Q9UQD0	Q92915
PDB IDs
Enriched GO Terms of Interacting Partners?
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