SCN8A and OS9

Data Source:
HPRD (in vivo)

		SCN8A	OS9
Description		sodium voltage-gated channel alpha subunit 8	OS9 endoplasmic reticulum lectin
Image		No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc Cell Junction Axon Cytoplasmic Vesicle Node Of Ranvier Axon Initial Segment	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding ATP Binding	Protease Binding Protein Binding Carbohydrate Binding
	Biological Process	Sodium Ion Transport Nervous System Development Peripheral Nervous System Development Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Membrane Depolarization During Action Potential	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress Transmembrane Transport Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs		Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (consumption score) ( 30940813) Chronotype ( 30696823) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Response to antidepressants and depression ( 27622933)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		4 interacting genes: FGF13 FGF14 GNAO1 MAPK14	19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A HSP90B1 LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 ZNF512B
Entrez ID		6334	10956
HPRD ID		09006	17804
Ensembl ID		ENSG00000196876	ENSG00000135506
Uniprot IDs		Q6B4S4 Q9UQD0	Q13438
PDB IDs			3AIH
Enriched GO Terms of Interacting Partners?
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