BGLAP and GGCX

Data Source:
HPRD (in vitro)

		BGLAP	GGCX
Description		bone gamma-carboxyglutamate protein	gamma-glutamyl carboxylase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Lumen Dendrite Vesicle Perikaryon	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Bone Hydroxyapatite Binding	Gamma-glutamyl Carboxylase Activity Vitamin Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Osteoblast Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cell Adhesion Cell Aging Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Response To Vitamin K Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Odontogenesis Response To Drug Response To Estrogen Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Insulin Stimulus	Cellular Protein Modification Process Blood Coagulation Peptidyl-glutamic Acid Carboxylation
Pathways		Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins RUNX2 regulates osteoblast differentiation	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9
Drugs		Menadione Phylloquinone gamma-carboxy-L-glutamic acid Gallium nitrate	Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
Diseases			Pseudoxanthoma elasticum, including: Pseudoxanthoma elasticum (PXE); Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS		Estimated glomerular filtration rate ( 30604766) Mean corpuscular hemoglobin concentration ( 20139978) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) White matter hyperintensity burden ( 25663218)	Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) High light scatter reticulocyte count ( 32888494) Myocardial infarction ( 26343387) Prostate cancer ( 21743467) Triglyceride levels ( 32203549)
Interacting Genes		6 interacting genes: ASPH CTSB CTSD CTSH CTSS GGCX	7 interacting genes: BGLAP F10 F2 F7 F9 PROC SRPK2
Entrez ID		632	2677
HPRD ID		00205	00665
Ensembl ID		ENSG00000242252	ENSG00000115486
Uniprot IDs		P02818	P38435
PDB IDs
Enriched GO Terms of Interacting Partners?
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