S100B and S100A4

Data Source:
BioGRID (two hybrid)

		S100B	S100A4
Description		S100 calcium binding protein B	S100 calcium binding protein A4
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Nucleus Neuron Projection Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Tau Protein Binding Calcium-dependent Protein Binding RAGE Receptor Binding	RNA Binding Actin Binding Calcium Ion Binding Protein Binding Identical Protein Binding Transition Metal Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Axonogenesis Central Nervous System Development Learning Or Memory Positive Regulation Of Cell Population Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Epithelial To Mesenchymal Transition Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Nuclear signaling by ERBB4 TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Olopatadine Calcium N-Formylmethionine Arundic acid (Z)-2-[2-(4-methylpiperazin-1-yl)benzyl]diazenecarbothioamide 2-[(5-hex-1-yn-1-ylfuran-2-yl)carbonyl]-N-methylhydrazinecarbothioamide Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Trifluoperazine Copper
Diseases
GWAS		Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Lymphocyte counts ( 22286170)	Blood protein levels ( 29875488) Pulse pressure ( 30578418)
Interacting Genes		46 interacting genes: ADTRP AGER AGTRAP AHNAK ANXA6 BCL2L2 CACYBP CALM1 CAPZA1 CEP20 CT45A5 DES DNAJC30 FBXO7 FBXW5 GFAP GUCY2D IMP4 IMPA1 IQGAP1 LNX1 MAL2 MAPT MDM2 MDM4 NDRG1 NKAPD1 PGM1 RABAC1 S100A1 S100A11 S100A2 S100A4 S100A6 S100A9 S100P S100Z SDCBP SPG21 STK38 SUGT1 TMEM159 TMEM239 TNIP1 TP53 VAV1	28 interacting genes: ACTA1 ANXA2 BAG6 CCN3 CEP20 EGFR FCGR3A HSPB1 MDM2 METAP2 MYH10 MYH2 MYH4 MYH9 PPFIBP1 RHOU S100A1 S100B S100P SEPTIN2 SEPTIN6 SEPTIN7 SMAD3 SRPK2 TP53 TPM2 TPM3 UNC119
Entrez ID		6285	6275
HPRD ID		01505	15914
Ensembl ID		ENSG00000160307	ENSG00000196154
Uniprot IDs		A0A0S2Z4C5 P04271	P26447
PDB IDs		1MQ1 1UWO 2H61 2M49 2PRU 3CZT 3D0Y 3D10 3HCM 4XYN 5CSF 5CSI 5CSJ 5CSN 5D7F	1M31 2LNK 2MRD 2Q91 3C1V 3CGA 3KO0 3M0W 3ZWH 4CFQ 4CFR 4ETO 4HSZ 5LPU 6T58
Enriched GO Terms of Interacting Partners?
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