S100A12 and CACYBP

Data Source:
HPRD (in vivo)

		S100A12	CACYBP
Description		S100 calcium binding protein A12	calcyclin binding protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Secretory Granule Lumen	Nucleus Nuclear Envelope Lumen Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Beta-catenin Destruction Complex Neuron Projection Cell Body Extracellular Exosome
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding	Protein Binding Tubulin Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity S100 Protein Binding
	Biological Process	Cytokine Production Monocyte Chemotaxis Xenobiotic Metabolic Process Inflammatory Response Neutrophil Chemotaxis Killing Of Cells Of Other Organism Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Innate Immune Response Mast Cell Activation Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Heart Development Aging Positive Regulation Of DNA Replication Cardiac Muscle Cell Differentiation Response To Growth Hormone Negative Regulation Of Cell Death Cellular Response To Calcium Ion Cellular Response To Leukemia Inhibitory Factor
Pathways		TAK1 activates NFkB by phosphorylation and activation of IKKs complex Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Olopatadine Amlexanox
Diseases
GWAS		Asthma ( 31619474) Blood protein levels ( 30072576) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		2 interacting genes: AGER CACYBP	20 interacting genes: BEX3 CCR2 CD8A ERBB2 FBXO7 HSP90AA1 HSP90B1 MAPK1 NPM1 PEA15 PINX1 PRKCA S100A1 S100A12 S100A6 S100B S100P SIAH1 SIAH2 SKP1
Entrez ID		6283	27101
HPRD ID		04383	07316
Ensembl ID		ENSG00000163221	ENSG00000116161
Uniprot IDs		P80511	A0A024R904 Q9HB71
PDB IDs		1E8A 1GQM 1ODB 2M9G 2WC8 2WCB 2WCE 2WCF	1X5M 2A25 2A26
Enriched GO Terms of Interacting Partners?
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