CACYBP and S100A12

Data Source:
HPRD (in vivo)

		CACYBP	S100A12
Description		calcyclin binding protein	S100 calcium binding protein A12
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Lumen Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Beta-catenin Destruction Complex Neuron Projection Cell Body Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Secretory Granule Lumen
	Molecular Function	Protein Binding Tubulin Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity S100 Protein Binding	Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Calcium-dependent Protein Binding RAGE Receptor Binding
	Biological Process	Heart Development Aging Positive Regulation Of DNA Replication Cardiac Muscle Cell Differentiation Response To Growth Hormone Negative Regulation Of Cell Death Cellular Response To Calcium Ion Cellular Response To Leukemia Inhibitory Factor	Cytokine Production Monocyte Chemotaxis Xenobiotic Metabolic Process Inflammatory Response Neutrophil Chemotaxis Killing Of Cells Of Other Organism Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Positive Regulation Of MAP Kinase Activity Innate Immune Response Mast Cell Activation Positive Regulation Of Inflammatory Response Defense Response To Fungus Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways			TAK1 activates NFkB by phosphorylation and activation of IKKs complex Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs			Olopatadine Amlexanox
Diseases
GWAS			Asthma ( 31619474) Blood protein levels ( 30072576) Matrix metalloproteinase-8 levels ( 29212897)
Interacting Genes		20 interacting genes: BEX3 CCR2 CD8A ERBB2 FBXO7 HSP90AA1 HSP90B1 MAPK1 NPM1 PEA15 PINX1 PRKCA S100A1 S100A12 S100A6 S100B S100P SIAH1 SIAH2 SKP1	2 interacting genes: AGER CACYBP
Entrez ID		27101	6283
HPRD ID		07316	04383
Ensembl ID		ENSG00000116161	ENSG00000163221
Uniprot IDs		A0A024R904 Q9HB71	P80511
PDB IDs		1X5M 2A25 2A26	1E8A 1GQM 1ODB 2M9G 2WC8 2WCB 2WCE 2WCF
Enriched GO Terms of Interacting Partners?
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