RYR1 and PDLIM3

Data Source:
BioGRID (two hybrid)

		RYR1	PDLIM3
Description		ryanodine receptor 1	PDZ and LIM domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Integral Component Of Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex	Stress Fiber Cytosol Adherens Junction Z Disc Filamentous Actin
	Molecular Function	Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Calcium Ion Cellular Response To Caffeine Regulation Of Cardiac Conduction	Heart Development Actin Cytoskeleton Organization Muscle Structure Development
Pathways		Stimuli-sensing channels Ion homeostasis
Drugs		Caffeine Dantrolene Suramin Tetracaine
Diseases		Central core disease
GWAS		Abstraction and mental flexibility ( 31596458) Appendicular lean mass ( 33097823) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)
Interacting Genes		19 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3	11 interacting genes: ABCA1 ACTN2 FHL1 MYOT MYOZ2 MYOZ3 MYPN PALLD RANBP2 RHOU RYR1
Entrez ID		6261	27295
HPRD ID		01618	08388
Ensembl ID		ENSG00000196218	ENSG00000154553
Uniprot IDs		P21817	A0A087WYF8 A0A2U3TZH4 Q53GG5
PDB IDs		6UHI 6UHS
Enriched GO Terms of Interacting Partners?
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