RYR1 and FKBP1A

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RYR1	FKBP1A
Description		ryanodine receptor 1	FKBP prolyl isomerase 1A
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GO Annotations	Cellular Component	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Integral Component Of Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex	Cytoplasm Cytosol Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Extrinsic Component Of Organelle Membrane Cytoplasmic Side Of Membrane Ryanodine Receptor Complex
	Molecular Function	Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Macrolide Binding FK506 Binding Calcium Channel Inhibitor Activity Type I Transforming Growth Factor Beta Receptor Binding Ion Channel Binding SMAD Binding Activin Binding
	Biological Process	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Calcium Ion Cellular Response To Caffeine Regulation Of Cardiac Conduction	Protein Peptidyl-prolyl Isomerization Heart Morphogenesis Protein Folding 'de Novo' Protein Folding SMAD Protein Complex Assembly Protein Maturation By Protein Folding Positive Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Negative Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Protein Localization Regulation Of Activin Receptor Signaling Pathway Protein Refolding T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Immune Response Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Heart Trabecula Formation Chaperone-mediated Protein Folding Calcium Ion Transmembrane Transport Supramolecular Fiber Organization Negative Regulation Of Transforming Growth Factor Beta1 Activation Regulation Of Amyloid Precursor Protein Catabolic Process Amyloid Fibril Formation
Pathways		Stimuli-sensing channels Ion homeostasis	mTORC1-mediated signalling Calcineurin activates NFAT Calcineurin activates NFAT TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR1 LBD Mutants in Cancer Potential therapeutics for SARS
Drugs		Caffeine Dantrolene Suramin Tetracaine	Pimecrolimus Tacrolimus Sirolimus (3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid Gpi-1046 Methyl Methylsulfinylmethyl Sulfide FKB-001 Heptyl glucoside L-709,587 (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine 4-hydroxybutan-2-one GPI-1485 Myristic acid (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE Dorsomorphin
Diseases		Central core disease
GWAS		Abstraction and mental flexibility ( 31596458) Appendicular lean mass ( 33097823) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		19 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3	30 interacting genes: ABI2 ACVR1B ACVRL1 AHSP APP BARD1 BMPR1A CDC42 DHFR ERBB2 ERBB3 ERBB4 FKBP4 GLMN HSP90AA1 ITPR1 MAPT MDM2 MID1 MTOR NLGN3 PPP3CA RYR1 RYR3 SF3B4 TGFB1 TGFB1I1 TGFBR1 TRPC3 YY1
Entrez ID		6261	2280
HPRD ID		01618	01741
Ensembl ID		ENSG00000196218	ENSG00000088832
Uniprot IDs		P21817	A0A087WTS4 P62942 Q0VDC6
PDB IDs		6UHI 6UHS	1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 2DG3 2DG4 2DG9 2FAP 2FKE 2ND5 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19 4ODP 4ODQ 4ODR 5I7P 5I7Q 6I1S 6M4U 6OQA
Enriched GO Terms of Interacting Partners?
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