PDLIM3 and RYR1

Data Source:
BioGRID (two hybrid)

		PDLIM3	RYR1
Description		PDZ and LIM domain 3	ryanodine receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Adherens Junction Z Disc Filamentous Actin	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Sarcoplasmic Reticulum Z Disc Cytoplasmic Vesicle Membrane Integral Component Of Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Calcium-release Channel Activity Calcium-induced Calcium Release Activity
	Biological Process	Heart Development Actin Cytoskeleton Organization Muscle Structure Development	Response To Hypoxia Outflow Tract Morphogenesis Calcium Ion Transport Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Caffeine Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Calcium Ion Cellular Response To Caffeine Regulation Of Cardiac Conduction
Pathways			Stimuli-sensing channels Ion homeostasis
Drugs			Caffeine Dantrolene Suramin Tetracaine
Diseases			Central core disease
GWAS			Abstraction and mental flexibility ( 31596458) Appendicular lean mass ( 33097823) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)
Interacting Genes		11 interacting genes: ABCA1 ACTN2 FHL1 MYOT MYOZ2 MYOZ3 MYPN PALLD RANBP2 RHOU RYR1	19 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3
Entrez ID		27295	6261
HPRD ID		08388	01618
Ensembl ID		ENSG00000154553	ENSG00000196218
Uniprot IDs		A0A087WYF8 A0A2U3TZH4 Q53GG5	P21817
PDB IDs			6UHI 6UHS
Enriched GO Terms of Interacting Partners?
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