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FKBP1A and ACVRL1
Data Source:
BioGRID
(two hybrid)
FKBP1A
ACVRL1
Description
FKBP prolyl isomerase 1A
activin A receptor like type 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Terminal Cisterna
Membrane
Sarcoplasmic Reticulum
Z Disc
Extrinsic Component Of Organelle Membrane
Cytoplasmic Side Of Membrane
Ryanodine Receptor Complex
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Receptor Complex
BMP Receptor Complex
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Macrolide Binding
FK506 Binding
Calcium Channel Inhibitor Activity
Type I Transforming Growth Factor Beta Receptor Binding
Ion Channel Binding
SMAD Binding
Activin Binding
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Protein Kinase Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
BMP Receptor Activity
Biological Process
Protein Peptidyl-prolyl Isomerization
Heart Morphogenesis
Protein Folding
'de Novo' Protein Folding
SMAD Protein Complex Assembly
Protein Maturation By Protein Folding
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Binding
Negative Regulation Of Phosphoprotein Phosphatase Activity
Regulation Of Protein Localization
Regulation Of Activin Receptor Signaling Pathway
Protein Refolding
T Cell Activation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Immune Response
Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Heart Trabecula Formation
Chaperone-mediated Protein Folding
Calcium Ion Transmembrane Transport
Supramolecular Fiber Organization
Negative Regulation Of Transforming Growth Factor Beta1 Activation
Regulation Of Amyloid Precursor Protein Catabolic Process
Amyloid Fibril Formation
Angiogenesis
Regulation Of Endothelial Cell Proliferation
Lymphangiogenesis
Blood Vessel Maturation
Blood Vessel Remodeling
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Endocardial Cushion Morphogenesis
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Negative Regulation Of Cell Adhesion
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Heart Development
Blood Circulation
Regulation Of Blood Pressure
Negative Regulation Of Cell Population Proliferation
Dorsal/ventral Pattern Formation
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Positive Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Dorsal Aorta Morphogenesis
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Focal Adhesion Assembly
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Endothelial Tube Morphogenesis
Retina Vasculature Development In Camera-type Eye
Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Endocardial Cushion To Mesenchymal Transition
Negative Regulation Of DNA Biosynthetic Process
Pathways
mTORC1-mediated signalling
Calcineurin activates NFAT
Calcineurin activates NFAT
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGFBR1 LBD Mutants in Cancer
Potential therapeutics for SARS
Signaling by BMP
Drugs
Pimecrolimus
Tacrolimus
Sirolimus
(3R)-4-(p-toluenesulfonyl)-1,4-thiazane-3-carboxylicacid-L-phenylalanine ethyl ester
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid
Gpi-1046
Methyl Methylsulfinylmethyl Sulfide
FKB-001
Heptyl glucoside
L-709,587
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine
4-hydroxybutan-2-one
GPI-1485
Myristic acid
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE
Dorsomorphin
ATP
Diseases
Hereditary hemorrhagic telangiectasia (HHT)
GWAS
Estimated glomerular filtration rate (
31152163
)
Hematocrit (
29403010
)
Hemoglobin (
29403010
32888494
)
Hemoglobin levels (
32327693
)
Lymphocyte counts (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Monocyte count (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
)
Platelet count (
32888494
)
Plateletcrit (
32888494
27863252
)
Urate levels (
23263486
)
White blood cell count (
32888494
27863252
)
Interacting Genes
30 interacting genes:
ABI2
ACVR1B
ACVRL1
AHSP
APP
BARD1
BMPR1A
CDC42
DHFR
ERBB2
ERBB3
ERBB4
FKBP4
GLMN
HSP90AA1
ITPR1
MAPT
MDM2
MID1
MTOR
NLGN3
PPP3CA
RYR1
RYR3
SF3B4
TGFB1
TGFB1I1
TGFBR1
TRPC3
YY1
13 interacting genes:
ACVR2A
BAMBI
CSNK2B
FKBP1A
GDF2
SMAD1
SNX6
TGFB1
TGFB3
TGFBR1
TGFBR2
TGFBRAP1
XIAP
Entrez ID
2280
94
HPRD ID
01741
03181
Ensembl ID
ENSG00000088832
ENSG00000139567
Uniprot IDs
A0A087WTS4
P62942
Q0VDC6
A0A0S2Z310
P37023
PDB IDs
1A7X
1B6C
1BKF
1BL4
1D6O
1D7H
1D7I
1D7J
1EYM
1F40
1FAP
1FKB
1FKD
1FKF
1FKG
1FKH
1FKI
1FKJ
1FKR
1FKS
1FKT
1J4H
1J4I
1J4R
1NSG
1QPF
1QPL
2DG3
2DG4
2DG9
2FAP
2FKE
2ND5
2PPN
2PPO
2PPP
2RSE
3FAP
3H9R
3MDY
4DH0
4FAP
4IPX
4N19
4ODP
4ODQ
4ODR
5I7P
5I7Q
6I1S
6M4U
6OQA
2LCR
3MY0
4FAO
6SF1
6SF2
6SF3
Enriched GO Terms of Interacting Partners
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