RTKN and RHOC

Data Source:
HPRD (two hybrid)

		RTKN	RHOC
Description		rhotekin	ras homolog family member C
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Actomyosin Contractile Ring Cytosol	Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cleavage Furrow Stereocilium Cell Projection Neuron Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	GTPase Inhibitor Activity Protein Binding GTP Binding Small GTPase Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Signal Transduction Rho Protein Signal Transduction Septin Ring Organization Negative Regulation Of GTPase Activity Regulation Of Apoptotic Process	Mitotic Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Positive Regulation Of Cell Migration Cortical Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins	Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: AKAP13 APP GOPC MAP1LC3A MFHAS1 RAC2 RHOA RHOC SMURF1 TAX1BP3 TGFBR1	8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN
Entrez ID		6242	389
HPRD ID		03795	01322
Ensembl ID		ENSG00000114993	ENSG00000155366
Uniprot IDs		Q9BST9	A0A024R0C8 P08134
PDB IDs			1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?
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