RRM1 and RNF2

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		RRM1	RNF2
Description		ribonucleotide reductase catalytic subunit M1	ring finger protein 2
Image
GO Annotations	Cellular Component	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding
	Biological Process	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Retina Development In Camera-type Eye	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Germ Cell Development Anterior/posterior Axis Specification Gene Expression Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of G0 To G1 Transition
Pathways		Interconversion of nucleotide di- and triphosphates	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs		Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon Gallium maltolate Tezacitabine
Diseases
GWAS		Malaria ( 31844061) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 27863252 28957414)	Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)
Interacting Genes		10 interacting genes: BMI1 CDC42 LRIF1 PPP1CC RNF2 RRM2 RRM2B SUMO2 YWHAG ZNF655	59 interacting genes: ABCB1 AMBRA1 AUTS2 BAALC BMI1 CASP3 CASP9 CBX2 CBX4 DYSF ERG H2AC18 H2AC20 H2AC4 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF1 PCGF2 PCGF3 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SIK1 SMURF2 SSX2 TARDBP TFCP2 TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W USP11 USP19 WASHC1 YAF2
Entrez ID		6240	6045
HPRD ID		01588	07028
Ensembl ID		ENSG00000167325	ENSG00000121481
Uniprot IDs		B4DXD1 B4E0I8 E9PL69 P23921	Q99496
PDB IDs		2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI 6L3R 6L7L	2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O
Enriched GO Terms of Interacting Partners?
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