SAV1 and POLE2

Data Source:
BioGRID (affinity chromatography technology)

		SAV1	POLE2
Description		salvador family WW domain containing protein 1	DNA polymerase epsilon 2, accessory subunit
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Dendrite	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Signaling Receptor Complex Adaptor Activity Beta-1 Adrenergic Receptor Binding Identical Protein Binding SMAD Binding Type II Activin Receptor Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	Hair Follicle Development Apoptotic Process Signal Transduction Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Apoptotic Process Receptor Clustering Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Regulation Of Stem Cell Population Maintenance	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA-dependent DNA Replication DNA Replication Initiation DNA Repair Telomere Maintenance Via Semi-conservative Replication Error-prone Translesion Synthesis
Pathways		Signaling by Hippo	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494 27863252) Periodontal disease-related phenotype (Socransky) ( 24347629) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: EP300 NEDD4 RASSF1 STK3 STK4	19 interacting genes: AGFG1 BAIAP2L2 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 PKM POLE POLE4 REL SAP18 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620
Entrez ID		60485	5427
HPRD ID		06229	16007
Ensembl ID		ENSG00000151748	ENSG00000100479
Uniprot IDs		B3KTQ1 Q9H4B6	P56282
PDB IDs		6AO5	2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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