SLC5A7 and PAWR

Data Source:
HPRD (in vivo, in vitro)

		SLC5A7	PAWR
Description		solute carrier family 5 member 7	pro-apoptotic WT1 regulator
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Axon Dendrite Neuromuscular Junction Perikaryon Synapse Presynapse	Chromatin Nucleus Cytoplasm Actin Filament Plasma Membrane Actin Cytoskeleton
	Molecular Function	Choline:sodium Symporter Activity Choline Transmembrane Transporter Activity Choline Binding	Transcription Corepressor Activity Actin Binding Protein Binding Enzyme Binding Leucine Zipper Domain Binding
	Biological Process	In Utero Embryonic Development Sodium Ion Transport Neurotransmitter Secretion Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Acetylcholine Biosynthetic Process Choline Transport Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Gene Expression Negative Regulation Of B Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Senescence
Pathways		Acetylcholine Neurotransmitter Release Cycle Transport of bile salts and organic acids, metal ions and amine compounds Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		1 interacting genes: PAWR	16 interacting genes: AATF ATP5F1C DAPK3 DRD2 HSPA5 PML PRKCZ RRAS2 SLC5A7 SPSB1 SPSB2 SPSB4 SQSTM1 TFPT THAP1 WT1
Entrez ID		60482	5074
HPRD ID		12294	09051
Ensembl ID		ENSG00000115665	ENSG00000177425
Uniprot IDs		B2RCU2 B4DUU7 Q2T9H3 Q9GZV3	Q96IZ0
PDB IDs			2JK9
Enriched GO Terms of Interacting Partners?
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