RIT2 and AFDN

Data Source:
HPRD (two hybrid)

		RIT2	AFDN
Description		Ras like without CAAX 2	afadin, adherens junction formation factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction
	Molecular Function	Chromatin Binding GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding Semaphorin Receptor Binding Identical Protein Binding	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	MAPK Cascade Regulation Of Protein Phosphorylation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Adherens Junction Organization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Signalling to p38 via RIT and RIN
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcohol consumption (drinks per week) ( 30679032) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 26426971 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 22451204 25064009 32201043 27182965 21738487 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2	37 interacting genes: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		6014	4301
HPRD ID		15253	01164
Ensembl ID		ENSG00000152214	ENSG00000130396
Uniprot IDs		Q99578	A8MQ02 G1UI22 J3KN01 P55196
PDB IDs			1T2M 1XZ9 2AIN 2EXG 5A6C
Enriched GO Terms of Interacting Partners?
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