RIT2 and POU4F1

Data Source:
HPRD (in vitro, two hybrid)

		RIT2	POU4F1
Description		Ras like without CAAX 2	POU class 4 homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Neuron Projection Cell Body Membrane Raft Synapse Dendritic Tree	Chromatin Nucleus Nucleoplasm Cytoplasm Neuron Projection RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Chromatin Binding GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding Semaphorin Receptor Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Single-stranded DNA Binding Protein Binding Sequence-specific DNA Binding GTPase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Regulation Of Protein Phosphorylation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Chemical Synaptic Transmission Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Regulation Of Endocytosis Regulation Of Cdc42 Protein Signal Transduction Maintenance Of Protein Location In Cell Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Calcium-mediated Signaling	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Ventricular Compact Myocardium Morphogenesis Regulation Of Transcription By RNA Polymerase II Axonogenesis Synapse Assembly Mesoderm Development Heart Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Migration In Hindbrain Trigeminal Nerve Development Central Nervous System Neuron Differentiation Habenula Development Neuron Projection Development Positive Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Sensory System Development Peripheral Nervous System Neuron Development Regulation Of Neurogenesis Regulation Of DNA-binding Transcription Factor Activity Proprioception Involved In Equilibrioception Innervation Positive Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription Elongation By RNA Polymerase I
Pathways		Signalling to p38 via RIT and RIN	Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Acute lymphoblastic leukemia (childhood) ( 23007406) Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcohol consumption (drinks per week) ( 30679032) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder ( 26314684) Body mass index ( 28552196 26426971 28892062) Brain morphology (MOSTest) ( 32665545) Cognitive performance ( 19734545) Coronary artery calcification ( 23870195) HDL cholesterol levels ( 32203549) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Parkinson's disease ( 22451204 25064009 32201043 27182965 21738487 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (PAL4Q3) ( 24024966) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist circumference ( 25673412) Weight ( 28552196)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		13 interacting genes: AFDN APP CALM1 HRAS PLXNB3 POU4F1 RAB5A RALGDS RGL1 RGL3 RLF SOS1 SRPK2	4 interacting genes: ESR1 EWSR1 MAPRE3 RIT2
Entrez ID		6014	5457
HPRD ID		15253	03379
Ensembl ID		ENSG00000152214	ENSG00000152192
Uniprot IDs		Q99578	Q01851
PDB IDs
Enriched GO Terms of Interacting Partners?
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