RFX1 and NFIB

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RFX1	NFIB
Description		regulatory factor X1	nuclear factor I B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Intracellular Membrane-bounded Organelle	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response	Chondrocyte Differentiation DNA Replication Regulation Of Transcription By RNA Polymerase II Brain Development Glial Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Anterior Commissure Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Lung Ciliated Cell Differentiation Commissural Neuron Axon Guidance Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Pathways			RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS			Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)
Interacting Genes		14 interacting genes: ABL1 ADD1 HIVEP2 HMGB1 MAGED1 NFIB NFIC NFIX RFX2 RFX3 SMAD1 SMAD4 SMAD9 TADA3	4 interacting genes: NFIA NFIC NFIX RFX1
Entrez ID		5989	4781
HPRD ID		02476	09008
Ensembl ID		ENSG00000132005	ENSG00000147862
Uniprot IDs		P22670	A0A0A0MRX8 O00712 Q5VW26 Q5VW28
PDB IDs		1DP7
Enriched GO Terms of Interacting Partners?
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