NFIB and NFIC

Data Source:
HPRD (in vitro)

		NFIB	NFIC
Description		nuclear factor I B	nuclear factor I C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber	Chromatin Fibrillar Center Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Chondrocyte Differentiation DNA Replication Regulation Of Transcription By RNA Polymerase II Brain Development Glial Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Anterior Commissure Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Lung Ciliated Cell Differentiation Commissural Neuron Axon Guidance Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)	Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103 31562340) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		4 interacting genes: NFIA NFIC NFIX RFX1	25 interacting genes: CBLC CREBBP DACH1 EPHA2 FBXO7 GLIS1 GLIS2 GLRX LATS2 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 RELA RFX1 SOX3 TEAD2 TH TKTL2 TLX1 TPD52L3 ZCCHC14 ZKSCAN7
Entrez ID		4781	4782
HPRD ID		09008	09009
Ensembl ID		ENSG00000147862	ENSG00000141905
Uniprot IDs		A0A0A0MRX8 O00712 Q5VW26 Q5VW28	B7Z4T6 P08651
PDB IDs
Enriched GO Terms of Interacting Partners?
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