NFIB and RFX1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		NFIB	RFX1
Description		nuclear factor I B	regulatory factor X1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Cerebellar Mossy Fiber	Chromatin Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chondrocyte Differentiation DNA Replication Regulation Of Transcription By RNA Polymerase II Brain Development Glial Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Anterior Commissure Morphogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Club Cell Differentiation Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Lung Ciliated Cell Differentiation Commissural Neuron Axon Guidance Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis	Regulation Of Transcription By RNA Polymerase II Immune Response
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Alcoholic chronic pancreatitis ( 28754779) Alzheimer's disease biomarkers ( 23419831) Ankle injury ( 28957384) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Metastasis at diagnosis in osteosarcoma ( 26084801) Red blood cell count ( 32888494)
Interacting Genes		4 interacting genes: NFIA NFIC NFIX RFX1	14 interacting genes: ABL1 ADD1 HIVEP2 HMGB1 MAGED1 NFIB NFIC NFIX RFX2 RFX3 SMAD1 SMAD4 SMAD9 TADA3
Entrez ID		4781	5989
HPRD ID		09008	02476
Ensembl ID		ENSG00000147862	ENSG00000132005
Uniprot IDs		A0A0A0MRX8 O00712 Q5VW26 Q5VW28	P22670
PDB IDs			1DP7
Enriched GO Terms of Interacting Partners?
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