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RFC1 and CDK4
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
RFC1
CDK4
Description
replication factor C subunit 1
cyclin dependent kinase 4
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
DNA Replication Factor C Complex
Nucleolus
Cytoplasm
Elg1 RFC-like Complex
Extracellular Exosome
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
Bicellular Tight Junction
Mediator Complex
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Cyclin D2-CDK4 Complex
Molecular Function
DNA Binding
DNA Clamp Loader Activity
Double-stranded DNA Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
Protein Domain Specific Binding
Sequence-specific DNA Binding
DNA Clamp Unloader Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Cyclin Binding
Protein-containing Complex Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA-dependent DNA Replication
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Telomere Maintenance Via Telomerase
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Transcription, DNA-templated
Regulation Of Catalytic Activity
Error-free Translesion Synthesis
DNA Clamp Unloading
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Lens Development In Camera-type Eye
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Signal Transduction
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To Lead Ion
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Animal Organ Regeneration
Cellular Response To Insulin Stimulus
Response To Testosterone
Regulation Of Multicellular Organism Growth
Response To Drug
Positive Regulation Of Apoptotic Process
Positive Regulation Of Translation
Positive Regulation Of Cell Cycle
Positive Regulation Of Cell Size
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Fibroblast Proliferation
Regulation Of Lipid Catabolic Process
Cell Division
Regulation Of Cell Cycle
Response To Hyperoxia
Adipose Tissue Development
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-4
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Ionomycin
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination
Transcriptional regulation of granulopoiesis
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Purvalanol
Alvocidib
Palbociclib
Ribociclib
Abemaciclib
Fostamatinib
Diseases
Glioma
Malignant melanoma
Cervical cancer
GWAS
Asthma (
30929738
)
Asthma (adult onset) (
30929738
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Reticulocyte count (
32888494
)
Brain morphology (MOSTest) (
32665545
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
30423114
24390342
)
Interacting Genes
19 interacting genes:
BRCA1
BRD4
CASP3
CCND1
CDK4
CEBPA
CSNK2B
HDAC1
MYOC
PCNA
RELA
RFC2
RFC3
SMC1A
SSBP3
TCEAL1
UBC
YWHAQ
ZSCAN1
134 interacting genes:
AKT1
ANKRD12
ANXA7
APLP1
APP
ARAF
ARID4A
ARNT
ATP5F1B
BAG6
BCL11A
BECN1
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CCNE1
CD44
CDC37
CDC45
CDC6
CDC7
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
CNTN2
DAZAP2
DDAH2
DUSP9
EIF4EBP2
EPHA2
ERBB2
FGFR4
FOXM1
FZR1
GLIS2
GRM1
H1-0
H1-1
H1-3
HGF
HIF1A
HMGXB3
HOOK1
HSP90AA1
IFI27
IGF1R
IKZF3
IL15RA
INCA1
KDELR2
LATS2
LNX2
LUC7L2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MAPRE2
MARCKS
MCM2
MDM4
MET
MYC
MYOD1
MZF1
NCOA2
NF2
NOL12
OGDHL
ORC3
OTX2
PDGFRA
PGD
PIAS1
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS1
RAF1
RASSF1
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
SPOP
STK11
STUB1
TEAD2
TERT
TGFBR1
TK1
TP53
TRMT2A
TSC1
TSPYL2
UBE3A
UBTF
UHRF2
USP17L2
VTA1
WDR33
YBX3
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
Entrez ID
5981
1019
HPRD ID
00024
00447
Ensembl ID
ENSG00000035928
ENSG00000135446
Uniprot IDs
P35251
A0A024RBB6
P11802
PDB IDs
2EBU
2K6G
2K7F
6VVO
1LD2
2W96
2W99
2W9F
2W9Z
3G33
5FWK
5FWL
5FWM
5FWP
6P8E
6P8F
6P8G
6P8H
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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