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CDK4 and RPL34
Data Source:
BioGRID
(pull down)
CDK4
RPL34
Description
cyclin dependent kinase 4
ribosomal protein L34
Image
GO Annotations
Cellular Component
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
Bicellular Tight Junction
Mediator Complex
Nuclear Membrane
Perinuclear Region Of Cytoplasm
Cyclin D2-CDK4 Complex
Endoplasmic Reticulum
Cytosol
Cytosolic Large Ribosomal Subunit
Extracellular Exosome
Molecular Function
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Cyclin Binding
Protein-containing Complex Binding
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Cadherin Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Lens Development In Camera-type Eye
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Signal Transduction
Circadian Rhythm
Positive Regulation Of Cell Population Proliferation
Response To Toxic Substance
Response To Lead Ion
Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Animal Organ Regeneration
Cellular Response To Insulin Stimulus
Response To Testosterone
Regulation Of Multicellular Organism Growth
Response To Drug
Positive Regulation Of Apoptotic Process
Positive Regulation Of Translation
Positive Regulation Of Cell Cycle
Positive Regulation Of Cell Size
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Fibroblast Proliferation
Regulation Of Lipid Catabolic Process
Cell Division
Regulation Of Cell Cycle
Response To Hyperoxia
Adipose Tissue Development
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-4
Cellular Response To Phorbol 13-acetate 12-myristate
Cellular Response To Ionomycin
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Viral Transcription
Pathways
SCF(Skp2)-mediated degradation of p27/p21
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
Ubiquitin-dependent degradation of Cyclin D
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates Cell Cycle
Transcriptional regulation by RUNX2
Meiotic recombination
Transcriptional regulation of granulopoiesis
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Purvalanol
Alvocidib
Palbociclib
Ribociclib
Abemaciclib
Fostamatinib
Diseases
Glioma
Malignant melanoma
Cervical cancer
GWAS
Brain morphology (MOSTest) (
32665545
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Rheumatoid arthritis (
30423114
24390342
)
Apolipoprotein A1 levels (
32203549
)
Blond vs. brown/black hair color (
30531825
)
Height (
25282103
)
Interacting Genes
134 interacting genes:
AKT1
ANKRD12
ANXA7
APLP1
APP
ARAF
ARID4A
ARNT
ATP5F1B
BAG6
BCL11A
BECN1
BIRC5
BMPR1B
BRCA1
CAMK1
CAPNS1
CCND1
CCND2
CCND3
CCNE1
CD44
CDC37
CDC45
CDC6
CDC7
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CDKN2D
CEBPA
CIB1
CNOT7
CNTN2
DAZAP2
DDAH2
DUSP9
EIF4EBP2
EPHA2
ERBB2
FGFR4
FOXM1
FZR1
GLIS2
GRM1
H1-0
H1-1
H1-3
HGF
HIF1A
HMGXB3
HOOK1
HSP90AA1
IFI27
IGF1R
IKZF3
IL15RA
INCA1
KDELR2
LATS2
LNX2
LUC7L2
MAP2K3
MAP2K5
MAP3K5
MAPK14
MAPRE2
MARCKS
MCM2
MDM4
MET
MYC
MYOD1
MZF1
NCOA2
NF2
NOL12
OGDHL
ORC3
OTX2
PDGFRA
PGD
PIAS1
PKM
POLD1
PPP2R1B
PRKAR1A
PSMD10
PTMA
QARS1
RAF1
RASSF1
RB1
RBL1
RBL2
RFC1
RFC4
RPL34
SENP3
SERTAD1
SETDB1
SHOX2
SKP1
SLBP
SMAD2
SMAD3
SNCA
SPOP
STK11
STUB1
TEAD2
TERT
TGFBR1
TK1
TP53
TRMT2A
TSC1
TSPYL2
UBE3A
UBTF
UHRF2
USP17L2
VTA1
WDR33
YBX3
ZBTB16
ZNF101
ZNF219
ZNF335
ZNF655
7 interacting genes:
APP
CDK4
CDK5
DAPK3
MAX
PTEN
SRPK2
Entrez ID
1019
6164
HPRD ID
00447
17996
Ensembl ID
ENSG00000135446
ENSG00000109475
Uniprot IDs
A0A024RBB6
P11802
A1LUY1
P49207
PDB IDs
1LD2
2W96
2W99
2W9F
2W9Z
3G33
5FWK
5FWL
5FWM
5FWP
6P8E
6P8F
6P8G
6P8H
4UG0
4V6X
5AJ0
5LKS
5T2C
6EK0
6IP5
6IP6
6IP8
6LQM
6LSR
6LSS
6LU8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6W6L
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
Enriched GO Terms of Interacting Partners
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