TTBK2 and KLHL12

Data Source:
BioGRID (two hybrid, two hybrid)

		TTBK2	KLHL12
Description		tau tubulin kinase 2	kelch like family member 12
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Centriole Cytosol Ciliary Transition Zone Ciliary Basal Body	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinesin Binding Tau Protein Binding Tau-protein Kinase Activity Microtubule Plus-end Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Smoothened Signaling Pathway Peptidyl-serine Phosphorylation Cerebellum Development Cerebellar Granular Layer Development Cerebellar Granule Cell Precursor Tangential Migration Regulation Of Cell Migration Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Protein Localization To Microtubule Negative Regulation Of Microtubule Binding	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Anchoring of the basal body to the plasma membrane	Degradation of DVL
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Bipolar disorder ( 31043756) Hematocrit ( 32888494) MGMT methylation in smokers ( 26183928)
Interacting Genes		1 interacting genes: KLHL12	62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL1 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		146057	59349
HPRD ID		10288	13925
Ensembl ID		ENSG00000128881	ENSG00000117153
Uniprot IDs		Q6IQ55 Q8IWY7	Q53G59 Q9H7R2
PDB IDs		6U0K 6VRF	2VPJ 6TTK 6V7O
Enriched GO Terms of Interacting Partners?
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