NEK1 and CSN2

Data Source:
HPRD (in vitro)

		NEK1	CSN2
Description		NIMA related kinase 1	casein beta
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Centriolar Satellite	Extracellular Region Extracellular Space
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Enzyme Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Protein Phosphorylation Cell Cycle Peptidyl-tyrosine Phosphorylation DNA Damage Response, Detection Of DNA Damage Cell Division Cilium Assembly	Calcium Ion Transport Lactation Negative Regulation Of Cysteine-type Endopeptidase Activity
Pathways			Nuclear signaling by ERBB4
Drugs		Fostamatinib
Diseases		Short rib-polydactyly syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Night sleep phenotypes ( 27126917) Schizophrenia ( 28991256 25056061 29483656) Supramarginal gyrus volume ( 31530798)
Interacting Genes		18 interacting genes: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD SIRPA TP53BP1 TSC2 YWHAH ZNF350	18 interacting genes: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK9 NFYC PLK1 RAC1 TOLLIP UBQLN2
Entrez ID		4750	1447
HPRD ID		06847	00281
Ensembl ID		ENSG00000137601	ENSG00000135222
Uniprot IDs		Q5JXL9 Q96PY6	P05814 W5RWE1
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?
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