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RBL2 and MCM7
Data Source:
HPRD
(in vitro)
RBL2
MCM7
Description
RB transcriptional corepressor like 2
minichromosome maintenance complex component 7
Image
GO Annotations
Cellular Component
Chromatin
Nucleoplasm
Transcription Regulator Complex
Chromosome
Nucleolus
Cytosol
Extracellular Exosome
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Membrane
MCM Complex
CMG Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
Protein Binding
Promoter-specific Chromatin Binding
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Single-stranded 3'-5' DNA Helicase Activity
Biological Process
Chromatin Organization
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Negative Regulation Of Gene Expression
Cell Differentiation
Regulation Of Lipid Kinase Activity
Regulation Of Cell Division
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Break-induced Replication
DNA Replication
Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Cellular Response To DNA Damage Stimulus
Cell Population Proliferation
Regulation Of Phosphorylation
Response To Drug
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Xenobiotic Stimulus
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
FOXO-mediated transcription of cell cycle genes
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
Drugs
Diseases
GWAS
Body fat mass (
28552196
)
General cognitive ability (
29844566
)
Height (
28552196
)
Intelligence (MTAG) (
29326435
)
Metabolite levels (
23823483
)
Brain morphology (MOSTest) (
32665545
)
Refractive error (
32231278
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
44 interacting genes:
BRCA1
BRF1
BRF2
CCNA1
CCNA2
CCND1
CCND3
CCNE1
CDK2
CDK4
CDK6
CREG1
DCTN1
DGKZ
E2F4
E2F5
EZH2
GRAMD4
HBP1
HDAC1
ID2
KMT5C
LBX1
LDHC
LIN52
MCM7
MNDA
PCBD1
PHB
PPP2CA
RAF1
RBBP8
RBBP9
RINT1
SKP2
SMARCA4
SNW1
SUV39H1
TAF1
TOP1
TP53BP1
UBTF
USP4
XBP1
77 interacting genes:
ABI2
AK8
APP
ASB8
C8orf34
CCDC102B
CCND1
CCNH
CDC42
CDC45
CDC6
CDC7
CDK7
CDKN1B
CEP68
CHEK1
COG6
CRLS1
DBF4
DNAAF6
DUX4
ELOC
ESCO2
FHL2
GOLGA2
H3-4
HIF1A
IKBKG
IKZF3
INTS6
KIFC3
LINC01554
LNX2
MAGEA6
MBIP
MCM10
MCM2
MCM3
MCM4
MCM5
MCM6
MCM8
MCMBP
MEOX2
MIPOL1
MNAT1
NAB2
NFKBIA
ORC1
ORC2
ORC3
ORC4
ORC5
ORC6
PLK1
PNMA1
RAD17
RB1
RBL1
RBL2
RBM8A
RBPMS
RINT1
RPA1
SMC1A
SNTA1
SP2
SSX2IP
TFIP11
TREX1
TRIM27
TRIM54
TRIM55
TRIM63
UBE3A
UBQLN1
USHBP1
Entrez ID
5934
4176
HPRD ID
01576
01154
Ensembl ID
ENSG00000103479
ENSG00000166508
Uniprot IDs
Q08999
A0A0S2Z4A5
C6EMX8
P33993
PDB IDs
4XI9
5C1D
6XTX
6XTY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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