RBL1 and PPP2R3A

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RBL1	PPP2R3A
Description		RB transcriptional corepressor like 1	protein phosphatase 2 regulatory subunit B''alpha
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex	Protein Phosphatase Type 2A Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Transcription Factor Binding Promoter-specific Chromatin Binding	Calcium Ion Binding Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Cycle Negative Regulation Of Gene Expression Viral Process Cell Differentiation Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence	Protein Dephosphorylation Regulation Of Phosphoprotein Phosphatase Activity Somite Development
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1
Drugs
Diseases
GWAS		Height ( 25429064) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 28957414)	Anticoagulant levels ( 22216198) Atrial fibrillation ( 30061737) Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling nervous ( 29500382) Feeling worry ( 29500382) Fibrinogen levels ( 28107422 26561523) General factor of neuroticism ( 30867560) High density lipoprotein cholesterol levels ( 31928498) Intraocular pressure ( 29617998) Neurofibrillary tangles ( 31497858) Neutrophil percentage of white cells ( 32888494) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498) Waist circumference adjusted for body mass index ( 25673412) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		54 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4	8 interacting genes: AKAP9 ATR ATXN7L2 CDC6 HMGB1 PPP5C PTPA RBL1
Entrez ID		5933	5523
HPRD ID		00312	09225
Ensembl ID		ENSG00000080839	ENSG00000073711
Uniprot IDs		P28749	Q06190
PDB IDs		1H28 4YOO 4YOS 4YOZ 5TUV	4I5J 4I5K
Enriched GO Terms of Interacting Partners?
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