RBL1 and E2F5

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid)

		RBL1	E2F5
Description		RB transcriptional corepressor like 1	E2F transcription factor 5
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex	Chromatin Fibrillar Center Nucleoplasm Nucleolus Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Transcription Factor Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Cycle Negative Regulation Of Gene Expression Viral Process Cell Differentiation Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence	Regulation Of Transcription By RNA Polymerase II Cell Projection Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS		Height ( 25429064) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 28957414)	Blood protein levels ( 28240269) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)
Interacting Genes		54 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4	8 interacting genes: CREBBP DNMT3L EP300 RBL1 RBL2 SMAD3 TFDP1 XPO1
Entrez ID		5933	1875
HPRD ID		00312	02983
Ensembl ID		ENSG00000080839	ENSG00000133740
Uniprot IDs		P28749	Q15329
PDB IDs		1H28 4YOO 4YOS 4YOZ 5TUV	5TUV
Enriched GO Terms of Interacting Partners?
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