BAG1 and HSPA1B

Data Source:
HPRD (two hybrid, in vitro)

		BAG1	HSPA1B
Description		BAG cochaperone 1	heat shock protein family A (Hsp70) member 1B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Chaperone Binding	Virus Receptor Activity G Protein-coupled Receptor Binding RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Protein Folding Chaperone Protein N-terminus Binding Unfolded Protein Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat	MRNA Catabolic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Cell Death Vesicle-mediated Transport Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Viral Entry Into Host Cell Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Regulation Of Mitotic Spindle Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Regulation of HSF1-mediated heat shock response	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Neutrophil degranulation
Drugs		(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Eosinophilic esophagitis ( 29904099) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		28 interacting genes: AR ARRB1 BCL2 BCL2L1 ESR1 HBEGF HSPA1A HSPA1B HSPA4 HSPA8 LRRK1 LRRK2 MAPT MET NR3C1 PDGFRB PPP1R15A PSMD1 PSMD2 PYGL RAF1 RARA RB1 SIAH1 STUB1 TRIM23 TRIM27 VDR	21 interacting genes: AIFM1 BAG1 BAG4 BNIP2 DNMBP F2RL1 FAF1 HSPBP1 MYBPC2 PGAM5 SGCG ST13 STIP1 STUB1 SUMO4 TGM2 TOMM70 TRIM38 TTN YWHAB YWHAZ
Entrez ID		573	3304
HPRD ID		03292	06784
Ensembl ID		ENSG00000107262	ENSG00000204388
Uniprot IDs		Q99933	A8K5I0 P0DMV8 P0DMV9
PDB IDs		1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV	1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?