ACTA2 and MYL1

Data Source:
HPRD (in vitro)

		ACTA2	MYL1
Description		actin alpha 2, smooth muscle	myosin light chain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome	Cytosol Muscle Myosin Complex Myofibril Sarcomere
	Molecular Function	ATP Binding Protein Kinase Binding	Calcium Ion Binding Structural Constituent Of Muscle
	Biological Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Transcription, DNA-templated Glomerular Mesangial Cell Development Mesenchyme Migration	Muscle Contraction Muscle Filament Sliding Cardiac Muscle Contraction
Pathways		Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription	Striated Muscle Contraction
Drugs		Phenethyl Isothiocyanate
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)	Serum metabolite levels ( 23093944)
Interacting Genes		18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1	7 interacting genes: ACTA1 ACTA2 ANKRD1 APP EPB41 IQGAP1 UBC
Entrez ID		59	4632
HPRD ID		00031	01180
Ensembl ID		ENSG00000107796	ENSG00000168530
Uniprot IDs		D2JYH4 P62736	P05976
PDB IDs
Enriched GO Terms of Interacting Partners?
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